Enterocyte Development and Migration
The goal of this project was to use vector graphics to create a diagram suitable for a textbook, explaining the migration and development of enterocytes that make up the intestinal lining.
Enterocytes make up the majority of the intestinal lining, originating from intestinal stem cells. From intestinal stem cells, the cells eventually terminally differentiate into 4 potential cell types as they are pushed from crypt to villus.
Client: Prof. Dave Mazierski & Dr. Shelley Wall
Media: Adobe Illustrator
Format: 8.5X11” page for biology textbook
Audience: Students
Date: February 2021
Process work
Research + Sketches
I reviewed the literature to understand the specifics of enterocyte development and migration. Sketches were developed to simplify the biomedical process through a schematized representation, using different colours and cell silhouettes to differentiate between the cell types. An associated figure description was also developed to accompany the figure’s migration steps.
References
Agur, A. M., & Dalley, A. F. (2019). Moores Essential Clinical Anatomy (Sixth Edition ed.). Wolters Kluwer. •
Birchenough, G. M. H., Johansson, M. E., Gustafsson, J. K., Bergström, J. H., & Hansson, G. C. (2015). New developments in goblet cell mucus secretion and function. Mucosal Immunology, 8(4), 712–719. https://doi.org/10.1038/mi.2015.32
Cui, S., & Chang, P.-Y. (2016). Current understanding concerning intestinal stem cells. World Journal of Gastroenterology, 22(31), 7099–7110. https://doi.org/10.3748/wjg.v22.i31.7099
Dey, I., & Bradbury, N. A. (2018). Chapter Ten - Physiology of the Gut: Experimental Models for Investigating Intestinal Fluid and Electrolyte Transport. In I. Levitane, E. Delpire, & H. Rasgado-Flores (Eds.), Current Topics in Membranes (Vol. 81, pp. 337–381). Academic Press. https://doi.org/10.1016/bs.ctm.2018.08.003
Gassler, N. (2017). Paneth cells in intestinal physiology and pathophysiology. World Journal of Gastrointestinal Pathophysiology, 8(4), 150–160. https://doi.org/10.4291/wjgp.v8.i4.150
Radtke, F., & Clevers, H. (2005). Self-Renewal and Cancer of the Gut: Two Sides of a Coin. Science, 307(5717), 1904–1909.
Serra, S., & Jani, P. A. (2006). An approach to duodenal biopsies. Journal of Clinical Pathology, 59(11), 1133–1150. https://doi.org/10.1136/jcp.2005.031260
Silverthorn, D. U., Garrison, C. W., Johnson, B. R., Ober, W. C., & Silverthorn, A. (2013). Human physiology: An integrated approach. In Human physiology: An integrated approach (pp. 701-710). Boston: London: Pearson.
Umar, S. (2010). Intestinal Stem Cells. Current Gastroenterology Reports, 12(5), 340–348. https://doi.org/10.1007/s11894-010-0130-3
Van der Flier, L. G., & Clevers, H. (2009). Stem Cells, Self-Renewal, and Differentiation in the Intestinal Epithelium. Annual Review of Physiology, 71, 241–260. https://doi.org/10.1146/annurev.physiol.010908.163145